CAT-005: Genetic Variant ENO4 and Male Infertility
Client Claim
“The ENO4 genetic variant causes male infertility and should inform clinical screening.”
AI Analysis (Automated)
- Identified association study
- Observed statistical correlation
- Suggested causal interpretation
⚠ Human disagreed with AI here
Human Expert Review
The AI conflated association with causation.
The study lacks mechanistic evidence and population-level replication.
Medical Review Board Response
Board initially supports AI output due to novelty and publication venue.
Final Expert Verdict
Claim is not clinically actionable.
Risk of premature implementation outweighs benefit.
Why This CAT Matters
- AI speed + human judgment
- Transparent disagreement
- Defensible decision trail
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